Spironolactone Q&A › Spironolactone Vote Up 0 Vote Down Wondering asked 8 months ago Hi everyone, I started taking 50mg of Spironolactone about 2 weeks ago and I haven’t seen an improvement in my B.O. For those of you who use it, how long does it take to work and what dosage do you take? Thanks! Please login or Register to submit your answer Username or Email Address Password Remember Me